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Test Code LAB4236/6866/CADM Cadmium, Blood

Important Note

Send Outs - Mayo

Additional Codes

Mayo Code: CDB


Specimen Required


Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Supplies: Metal Free B-D Tube (EDTA), 6 mL (T183)

Container/Tube: Royal blue-top (EDTA) plastic trace element blood collection tube

Specimen Volume: Full tube

Collection Instructions: Send specimen in original tube.

Additional Information: If ordering the trace element blood collection tube from BD, order catalog #368381.


Method Name

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Reporting Name

Cadmium, B

Specimen Type

Whole blood

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Day(s) and Time(s) Performed

Monday through Saturday; 2 p.m.

Analytic Time

1 day

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

82300

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CDB Cadmium, B 5609-3

 

Result ID Test Result Name Result LOINC Value
8682 Cadmium, B 5609-3

Useful For

Detecting exposure to cadmium, a toxic heavy metal

Clinical Information

The toxicity of cadmium resembles the other heavy metals (arsenic, mercury, and lead) in that it attacks the kidney; renal dysfunction with proteinuria with slow onset (over a period of years) is the typical presentation.

 

Breathing the fumes of cadmium vapors leads to nasal epithelial deterioration and pulmonary congestion resembling chronic emphysema.

 

The most common source of chronic exposure comes from spray painting of organic-based paints without use of a protective breathing apparatus; auto repair mechanics represent a susceptible group for cadmium toxicity. In addition, another common source of cadmium exposure is tobacco smoke.

Interpretation

Normal blood cadmium is <5.0 ng/mL, with most results in the range of 0.5 to 2.0 ng/mL.

 

Acute toxicity will be observed when the blood level exceeds 50 ng/mL.

Cautions

No significant cautionary statements

Clinical Reference

1. Moreau T, Lellouch J, Juguet B, et al: Blood cadmium levels in a general population with special reference to smoking. Arch Environ Health. 1983;38:163-167

2. Strathmann FG, Blum LM: Toxic Elements. In: Rafai N, Horwath AR., Wittwer CT, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 6th ed. Elsevier, 2018;chap 42

Method Description

Cadmium (Cd)is analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) in kinetic energy discrimination (KED) mode using helium as a non-reactive gas to collide with polyatomic interferences such as argon chloride (ArCl). Internal standard used is rhodium (Rh). A salt matrix calibration is used.(Unpublished Mayo method)

Specimen Retention Time

14 days

Specimen Minimum Volume

0.3 mL

Reference Values

<5.0 ng/mL

Reference values apply to all ages.

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole blood Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days